No it doesn't, and it's been a long time problem. The time with Constance was really strange because I didn't do much with her. Just had her wander around in game a bit to make sure I was happy with her appearance before importing her face into the Companion Constance mod. Then I loaded Aeronwen's last save and "boom" all the saves except for the first one started crashing.

The reason I went in on my Hidden Elf was that I wanted to see what the world is like when the Oblivion portals start spawning. Apparently that was enough to kill my main game.